- Title
- Enzymatic hydrolysis of monoacylglycerols and their cyclopropanated derivatives: molecular structure and nanostructure determine the rate of digestion
- Creator
- Manni, Livia Salvati; Duss, Michael; Assenza, Salvatore; Boyd, Ben J.; Landau, Ehud M.; Fong, Wye-Khay
- Relation
- Journal of Colloid and Interface Science Vol. 588, Issue 15 April 2021, p. 767-775
- Publisher Link
- http://dx.doi.org/10.1016/j.jcis.2020.11.110
- Publisher
- Elsevier
- Resource Type
- journal article
- Date
- 2021
- Description
- Colloidal lipidic particles with different space groups and geometries (mesosomes) are employed in the development of new nanosystems for the oral delivery of drugs and nutrients. Understanding of the enzymatic digestion rate of these particles is key to the development of novel formulations. In this work, the molecular structure of the lipids has been systematically tuned to examine the effect on their self-assembly and digestion rate. The kinetic and phase changes during the lipase-catalysed hydrolysis of mesosomes formed by four synthetic cyclopropanated lipids and their cis-unsaturated analogues were monitored by dynamic small angle X-ray scattering and acid/base titration. It was established that both the phase behaviour and kinetics of the hydrolysis are greatly affected by small changes in the molecular structure of the lipid as well as by the internal nanostructure of the colloidal particles.
- Subject
- lipids; mesophases; cubic phases; hexagonal phases; enzymatic hydrolysis; phase behaviour; SAXS; nanostructured lipids; lipid nanoparticles; cyclopropanated lipids
- Identifier
- http://hdl.handle.net/1959.13/1423462
- Identifier
- uon:37941
- Identifier
- ISSN:0021-9797
- Language
- eng
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